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Santana's Room is a location you are teleported to by successfully using Santana's Meat Invade move. The room is used to simulate the Santana user being inside the host, despite the room being completely unseen without exploiting glitches. The room is only lit by an invisible, dim red light in the center of the room.
An easy way to see the room is to use Meat Invade, then have the host switch their Stand. Instead of teleporting to the host's location, the Santana user is now stuck in the room until they reset or leave the game.
While inside the room, the user's face disappears.
It is theoretically possible to use Meat Invade on a Santana user who uses Meat Invade on someone else, causing the first Santana user to pop out of the second Santana user, who would be in Santana's Room.